USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: Q96HG5 USC-OGP 2-DE database:  Q96HG5 Q96HG5 General information about the entry View entry in simple text format Entry name Q96HG5 Primary accession number Q96HG5 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Actin, cytoplasmic 1; AltName: Full=Beta-actin; Contains: RecName: Full=Actin, cytoplasmic 1, N-terminally processed;. Gene name Name=ACTB Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1185: pI=6.07; Mw=43048 SPOT OGP-1260: pI=5.04; Mw=29946 Cross-references UniProtKB/Swiss-Prot P60709; ACTB_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name ACTB_HUMAN Primary accession number P60709 Secondary accession number(s) P02570 P70514 P99021 Q11211 Q64316 Q75MN2 Q96B34 Q96HG5 Sequence was last modified on  April 1, 1988 (version 1) Annotations were last modified on  March 15, 2017 (version 161) Name and origin of the protein Description RecName: Full=Actin, cytoplasmic 1; AltName: Full=Beta-actin; Contains: RecName: Full=Actin, cytoplasmic 1, N-terminally processed; Gene name Name=ACTB Encoded on Name=ACTB Keywords 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Deafness; Direct protein sequencing; Disease mutation; Dystonia; Isopeptide bond; Mental retardation; Methylation; Nucleotide-binding; Oxidation; Polymorphism; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X00351; CAA25099.1; -; mRNA EMBL M10277; AAA51567.1; -; Genomic_DNA EMBL X63432; CAA45026.1; -; mRNA EMBL AY582799; AAS79319.1; -; Genomic_DNA EMBL AC006483; AAP22343.1; -; Genomic_DNA EMBL BC001301; AAH01301.1; -; mRNA EMBL BC002409; AAH02409.1; -; mRNA EMBL BC004251; AAH04251.1; -; mRNA EMBL BC008633; AAH08633.1; -; mRNA EMBL BC012854; AAH12854.1; -; mRNA EMBL BC013380; AAH13380.1; -; mRNA EMBL BC014861; AAH14861.1; -; mRNA EMBL BC016045; AAH16045.1; -; mRNA EMBL V00478; CAA23745.1; -; mRNA CCDS CCDS5341.1; -; . PIR A25168; ATHUB; . RefSeq NP_001092.1; NM_001101.3; . UniGene Hs.520640; -; . PDB 3BYH; EM; 12.00 A; A=2-375 PDB 3D2U; X-ray; 2.21 A; C/G=170-178 PDB 3J82; EM; 7.70 A; B/C/D=2-375 PDB 3LUE; EM; -; A/B/C/D/E/F/G/H/I/J=2-375 PDBsum 3BYH; -; . PDBsum 3D2U; -; . PDBsum 3J82; -; . PDBsum 3LUE; -; . ProteinModelPortal P60709; -; . SMR P60709; -; . BioGrid 106575; 281; . DIP DIP-29686N; -; . IntAct P60709; 197; . MINT MINT-220312; -; . STRING 9606.ENSP00000349960; -; . ChEMBL CHEMBL2062353; -; . iPTMnet P60709; -; . PhosphoSitePlus P60709; -; . SwissPalm P60709; -; . BioMuta ACTB; -; . DMDM 46397333; -; . DOSAC-COBS-2DPAGE P60709; -; . REPRODUCTION-2DPAGE P60709; -; . SWISS-2DPAGE P60709; -; . UCD-2DPAGE P60709; -; . EPD P60709; -; . PaxDb P60709; -; . PeptideAtlas P60709; -; . PRIDE P60709; -; . TopDownProteomics P60709; -; . DNASU 60; -; . Ensembl ENST00000331789; ENSP00000349960; ENSG00000075624; . GeneID 60; -; . KEGG hsa:60; -; . CTD 60; -; . DisGeNET 60; -; . GeneCards ACTB; -; . HGNC HGNC:132; ACTB; . HPA CAB002621; -; . HPA HPA041264; -; . HPA HPA041271; -; . MalaCards ACTB; -; . MIM 102630; gene; . MIM 243310; phenotype; . MIM 607371; phenotype; . neXtProt NX_P60709; -; . OpenTargets ENSG00000075624; -; . Orphanet 2995; Baraitser-Winter syndrome; . Orphanet 79107; Developmental malformations - deafness - dystonia; . PharmGKB PA24457; -; . eggNOG KOG0676; Eukaryota; . eggNOG COG5277; LUCA; . GeneTree ENSGT00760000118957; -; . HOVERGEN HBG003771; -; . InParanoid P60709; -; . KO K05692; -; . OMA PFHTTAE; -; . OrthoDB EOG091G08LD; -; . PhylomeDB P60709; -; . TreeFam TF354237; -; . Reactome R-HSA-1445148; Translocation of GLUT4 to the plasma membrane; . Reactome R-HSA-190873; Gap junction degradation; . Reactome R-HSA-196025; Formation of annular gap junctions; . Reactome R-HSA-2029482; Regulation of actin dynamics for phagocytic cup formation; . Reactome R-HSA-3214847; HATs acetylate histones; . Reactome R-HSA-389957; Prefoldin mediated transfer of substrate to CCT/TriC; . Reactome R-HSA-390450; Folding of actin by CCT/TriC; . Reactome R-HSA-3928662; EPHB-mediated forward signaling; . Reactome R-HSA-3928665; EPH-ephrin mediated repulsion of cells; . Reactome R-HSA-418990; Adherens junctions interactions; . Reactome R-HSA-437239; Recycling pathway of L1; . Reactome R-HSA-4420097; VEGFA-VEGFR2 Pathway; . Reactome R-HSA-445095; Interaction between L1 and Ankyrins; . Reactome R-HSA-446353; Cell-extracellular matrix interactions; . Reactome R-HSA-5250924; B-WICH complex positively regulates rRNA expression; . Reactome R-HSA-5626467; RHO GTPases activate IQGAPs; . Reactome R-HSA-5663213; RHO GTPases Activate WASPs and WAVEs; . Reactome R-HSA-5663220; RHO GTPases Activate Formins; . Reactome R-HSA-5674135; MAP2K and MAPK activation; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5696394; DNA Damage Recognition in GG-NER; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802948; Signaling by high-kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . Reactome R-HSA-8856828; Clathrin-mediated endocytosis; . Reactome R-HSA-983231; Factors involved in megakaryocyte development and platelet production; . SignaLink P60709; -; . ChiTaRS ACTB; human; . EvolutionaryTrace P60709; -; . GeneWiki Beta-actin; -; . GenomeRNAi 60; -; . PRO PR:P60709; -; . Proteomes UP000005640; Chromosome 7; . Bgee ENSG00000075624; -; . CleanEx HS_ACTB; -; . ExpressionAtlas P60709; baseline and differential; . Genevisible P60709; HS; . GO GO:0072562; C:blood microparticle; IDA:UniProtKB; . GO GO:0030863; C:cortical cytoskeleton; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL; . GO GO:0005856; C:cytoskeleton; TAS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0097433; C:dense body; ISS:AgBase; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:UniProtKB; . GO GO:0000790; C:nuclear chromatin; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005886; C:plasma membrane; ISS:AgBase; . GO GO:0043234; C:protein complex; IDA:UniProtKB; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0019894; F:kinesin binding; IPI:UniProtKB; . GO GO:0050998; F:nitric-oxide synthase binding; IPI:BHF-UCL; . GO GO:0005200; F:structural constituent of cytoskeleton; TAS:UniProtKB; . GO GO:0098973; F:structural constituent of postsynaptic actin cytoskeleton; IDA:SynGO; . GO GO:0030957; F:Tat protein binding; IPI:BHF-UCL; . GO GO:0043044; P:ATP-dependent chromatin remodeling; IDA:UniProtKB; . GO GO:0034329; P:cell junction assembly; TAS:Reactome; . GO GO:0048013; P:ephrin receptor signaling pathway; TAS:Reactome; . GO GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0006928; P:movement of cell or subcellular component; TAS:UniProtKB; . GO GO:0070527; P:platelet aggregation; IMP:UniProtKB; . GO GO:0045815; P:positive regulation of gene expression; epigenetic; TAS:Reactome GO GO:0098974; P:postsynaptic actin cytoskeleton organization; IDA:SynGO; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0001895; P:retina homeostasis; IEP:UniProtKB; . GO GO:0021762; P:substantia nigra development; IEP:UniProtKB; . GO GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; TAS:Reactome; . InterPro IPR004000; Actin; . InterPro IPR020902; Actin/actin-like_CS; . InterPro IPR004001; Actin_CS; . PANTHER PTHR11937; PTHR11937; 1; . Pfam PF00022; Actin; 1; . PRINTS PR00190; ACTIN; . SMART SM00268; ACTIN; 1; . PROSITE PS00406; ACTINS_1; 1; . PROSITE PS00432; ACTINS_2; 1; . PROSITE PS01132; ACTINS_ACT_LIKE; 1; .

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